Mandsaur is situated on Ajmer-Lebad(Indore) NH-79 as well as Mhow-Neemuch SH-31 4 Lane road.
Mandsaur is situated on Ajmer-Akola track of Indian Railways and is under Ratlam rail division of WR. Mandsaur has direct trains for Mumbai, Hyderabad, Kolkata, Jaipur, Ajmer, Udaipur, Agra, Kota, Indore, Ujjain, Bhopal, Ratlam,Bangalore.
The major trains passing from Mandsaur are:-
Ajmer/Udaipur-Bandra Terminus SF Express
Ratlam-Ajmer Express (Night)
Ratlam-Agra Fort Express
Auto and Tempo are main source of local transport in Mandsaur